Sub-angstrom accuracy in protein loop reconstruction by robotics-inspired conformational sampling
نویسندگان
چکیده
منابع مشابه
Improvements to Robotics-Inspired Conformational Sampling in Rosetta
To accurately predict protein conformations in atomic detail, a computational method must be capable of sampling models sufficiently close to the native structure. All-atom sampling is difficult because of the vast number of possible conformations and extremely rugged energy landscapes. Here, we test three sampling strategies to address these difficulties: conformational diversification, intens...
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ژورنال
عنوان ژورنال: Nature Methods
سال: 2009
ISSN: 1548-7091,1548-7105
DOI: 10.1038/nmeth0809-551